PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID2296
Carbohydrate NameCore oligosaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeShigella spp.   (NCBI Taxonomy)   (Drugpedia)
Basic StructureLPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The O-antigen consists of the following residues : -3)-β-D-Quip4NAc-(1-->2)-α-D-Manp [branched to α-L-Rhap-(1-->3)] -(1-->4)-β-D-Galp-(1-->3)-α-D-GlcpNAc-(1-
BCSDB StructureN/A
Proposed functionsLPS plays an important virulence role based on its antiphagocytic and endotoxic properties
Antigenic Nature used to produce antibodiesHeat killed cells
Carrier NameNil
Conjugation MethodNil
AntibodiesMab 5E45D8
Antibody type and classN/A
Assay SystemIndirect ELISA
Cross-reactivityThis Mab was specific to S. flexneri
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab has potential importance in immunological detection of Shigella from unknown samples
Curator IDAA + AS
Date of Curation24-03-2011
References11394534


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