PolysacDB ID | 1793 |
Carbohydrate Name | N-propionylated group B meningococcal polysaccharide (Drugpedia) |
Carbohydrate Class | Capsular polysaccharide |
Microbe | Neisseria meningitidis (NCBI Taxonomy) (Drugpedia) |
Basic Structure | It consists of a homopolymer of α(2-->8)-linked sialic acid residues
|
BCSDB Structure | N/A |
Proposed functions | It is an important virulence factor |
Antigenic Nature used to produce antibodies | Glycoconjugates |
Carrier Name | Tetanus toxoid |
Conjugation Method | N-propionylated group B meningococcal polysaccharide was combined with freshly purified monomeric tetanus toxoid in a solution of phosphate buffer containing NaBH3CN and incubated at 37°C for 5 days |
Antibodies | Mab 6B9 |
Antibody type and class | IgG2a |
Assay System | ELISA, bactericidal assays |
Cross-reactivity | N/A |
Proposed epitopes | The epitope was located only on extended helical segments of the polysaccharide and also comprised short internal fragments |
IEDB Epitope | N/A |
Proposed Utility | This Mab would help in the elucidation of the capsular polysaccharide structure |
Curator ID | AA + AS |
Date of Curation | 02-11-2010
|
References | PMC2196336 |