PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID1793
Carbohydrate NameN-propionylated group B meningococcal polysaccharide   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
MicrobeNeisseria meningitidis   (NCBI Taxonomy)   (Drugpedia)
Basic StructureIt consists of a homopolymer of α(2-->8)-linked sialic acid residues
BCSDB StructureN/A
Proposed functionsIt is an important virulence factor
Antigenic Nature used to produce antibodiesGlycoconjugates
Carrier NameTetanus toxoid
Conjugation MethodN-propionylated group B meningococcal polysaccharide was combined with freshly purified monomeric tetanus toxoid in a solution of phosphate buffer containing NaBH3CN and incubated at 37°C for 5 days
AntibodiesMab 6B9
Antibody type and classIgG2a
Assay SystemELISA, bactericidal assays
Cross-reactivityN/A
Proposed epitopesThe epitope was located only on extended helical segments of the polysaccharide and also comprised short internal fragments
IEDB EpitopeN/A
Proposed UtilityThis Mab would help in the elucidation of the capsular polysaccharide structure
Curator IDAA + AS
Date of Curation02-11-2010
ReferencesPMC2196336


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