| PolysacDB ID | 1611 |
| Carbohydrate Name | N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a homopolymer of α(2-->8) sialic acid
|
| BCSDB Structure | N/A |
| Proposed functions | This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins |
| Antigenic Nature used to produce antibodies | Whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab 735D4 |
| Antibody type and class | IgG2a |
| Assay System | ELISA, Immunoelectrophoresis and immunodiffusion |
| Cross-reactivity | This Mab reacted with with all E. coli K1 and group B meningococcal strains tested but did not react with E. coli strains having capsular types K12, K13, K14, and K92; and group A and C meningococci |
| Proposed epitopes | The epitope was proposed to consist of repeating α(2-->8)-linked Neu5Ac units |
| IEDB Epitope | N/A |
| Proposed Utility | This antibody is an important addition to the analyticaln tools available for the study of the structure and function of the E. coli K1 and meningococcal B capsules |
| Curator ID | AA + AS |
| Date of Curation | 22-09-2010
|
| References | 397221 |