| PolysacDB ID | 1616 |
| Carbohydrate Name | Lipooligosaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Moraxella catarrhalis (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | LOS consists of an oligosaccharide and lipid A and is similar to the lipopolysaccharide (LPS) of gramnegative enteric pathogens, but it lacks the O-antigenic side chain of repeating units characteristic of classical LPS. The oligosaccharide part consists of the following residues : α-D-Galp-(1-->4)-β-D-Galp-(1-->4)-α-D-Glcp-(1-->2)-β-D-Glcp-(1-->6)-α-D-Glcp [branched to α-D-GlcpNAc-(1-->2)-β-D-Glcp-(1-->4)] and [branched to β-D-Glcp-(1-->3)] -(1-->5)-Kdo[ branched to Kdop-(2-?)]
|
| BCSDB Structure | 22728 |
| Proposed functions | Moracella lipooligosaccharide is a potential virulence factor |
| Antigenic Nature used to produce antibodies | Whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab 8E7 |
| Antibody type and class | IgG3 |
| Assay System | ELISA, immunoblotting, Bacterial adherence assay, Bactericidal assay and immunoelectron microscopy |
| Cross-reactivity | MAb 8E7 reacted with M. catarrhalis O35E, serotype A and C LOSs but not serotype B LOS |
| Proposed epitopes | The epitope recognized by MAb 8E7 is directed to a common sequence of either α-GlcNAc-(1-->2)-β-Glc-(1--> at the branch substituting position 4 of the trisubstituted Glc residue or a terminal tetrasaccharide α-Gal-(1-->4)-β-Gal-(1-->4)-α-Glc-(1-->2)-β-Glc-[1--> at the branch substituting position 6 of the trisubstituted Glc residue |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab had had bactericidal activity. Passive immunization with Mab 8E7 could significantly enhance the clearance of strain O35E from mouse lungs in an aerosol challenge mouse model |
| Curator ID | AA + AS |
| Date of Curation | 23-09-2010
|
| References | PMC98028 |