PolysacDB ID | 2512 |
Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
Carbohydrate Class | Lipopolysaccharide |
Microbe | Vibrio cholerae 01 serogroup (NCBI Taxonomy) (Drugpedia) |
Basic Structure | It is a linear unbranched homopolymer of 1,6-linked-D-galactopyranosyl residues. |
BCSDB Structure | 6642 |
Proposed functions | V. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera |
Antigenic Nature used to produce antibodies | Killed Vaccine consisting of V. cholerae O1 Inaba (ATCC 14033) and Ogawa (ATCC 14035) cells |
Carrier Name | Nil |
Conjugation Method | Nil |
Antibodies | Mab A11 |
Antibody type and class | N/A |
Assay System | Enzyme-linked immunosorbent assay (ELISA), immunofluorescence, Immunoelectron microscopy and the slide agglutination test |
Cross-reactivity | This antibody reacted with the Ogawa serovars only (B antigen) |
Proposed epitopes | The epitope was named as Epitope B |
IEDB Epitope | N/A |
Proposed Utility | This Mab can be used for the utility to detect cholera vibrios in direct fecal smears |
Curator ID | AA + AS |
Date of Curation | 11-06-2011
|
References | PMC266720 |