PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID1654
Carbohydrate NameLipoarabinomannan   (Drugpedia)
Carbohydrate ClassGlycolipid
MicrobeMycobacterium leprae   (NCBI Taxonomy)   (Drugpedia)
Basic StructureLipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate
BCSDB Structure127448
Proposed functionsT cell proliferation and to interfere with gamma interferon-mediated activation of macrophages
Antigenic Nature used to produce antibodiesA combination of M. leprae 30KS and 1OKP
Carrier NameNil
Conjugation MethodNil
AntibodiesMab A12B
Antibody type and classIgG1
Assay SystemELISA, immunoblotting
Cross-reactivityThis Mab was specific for M. leprae LAM
Proposed epitopesα(1-->5)-linked arabinofuranosyl residues seemed to be a part of the epitope
IEDB EpitopeN/A
Proposed UtilityThis Mab would help in the structure elucidation of lipoarabinomanna
Curator IDAA + AS
Date of Curation30-09-2010
ReferencesPMC259992


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