PolysacDB ID | 1635 |
Carbohydrate Name | Phenolic glycolipid antigen (Drugpedia) |
Carbohydrate Class | Glycolipid |
Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
Basic Structure | It consisting of terminal 3,6-di-O-methyl glucose linked β1-->4 to 2,3-di-O-methyl rhamnose, which in turn is linked α1-->2 to 3-O-methyl rhamnose
|
BCSDB Structure | 114263 |
Proposed functions | It has been proposed to protect pathogenic mycobacteria such as Mycobacterium lepraemurium from the host bactericidal activities in phagocytic cells |
Antigenic Nature used to produce antibodies | Partially purified phenolic glycolipid from M. leprae |
Carrier Name | Nil |
Conjugation Method | Nil |
Antibodies | Mab A2A |
Antibody type and class | IgM |
Assay System | ELISA, TLC autoradiography and immunofluorescence |
Cross-reactivity | This Mab was specific to M. leprae glycolipid |
Proposed epitopes | Terminal 3,6-di-O-methyl glucose residues were proposed to be a part of the epitope |
IEDB Epitope | 76895 |
Proposed Utility | This Mab may provide more information on the structure of phenolic glycolipid of M. leprae and the localization of this antigen can be performed within infected lesions by immunofluorescence |
Curator ID | AA + AS |
Date of Curation | 26-09-2010
|
References | PMC263407 |