PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID1635
Carbohydrate NamePhenolic glycolipid antigen   (Drugpedia)
Carbohydrate ClassGlycolipid
MicrobeMycobacterium leprae   (NCBI Taxonomy)   (Drugpedia)
Basic StructureIt consisting of terminal 3,6-di-O-methyl glucose linked β1-->4 to 2,3-di-O-methyl rhamnose, which in turn is linked α1-->2 to 3-O-methyl rhamnose
BCSDB Structure114263
Proposed functionsIt has been proposed to protect pathogenic mycobacteria such as Mycobacterium lepraemurium from the host bactericidal activities in phagocytic cells
Antigenic Nature used to produce antibodiesPartially purified phenolic glycolipid from M. leprae
Carrier NameNil
Conjugation MethodNil
AntibodiesMab A2A
Antibody type and classIgM
Assay SystemELISA, TLC autoradiography and immunofluorescence
Cross-reactivityThis Mab was specific to M. leprae glycolipid
Proposed epitopesTerminal 3,6-di-O-methyl glucose residues were proposed to be a part of the epitope
IEDB Epitope76895
Proposed UtilityThis Mab may provide more information on the structure of phenolic glycolipid of M. leprae and the localization of this antigen can be performed within infected lesions by immunofluorescence
Curator IDAA + AS
Date of Curation26-09-2010
ReferencesPMC263407


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