PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID1548
Carbohydrate NameLipophosphoglycan   (Drugpedia)
Carbohydrate ClassGlycolipid
MicrobeLeishmania mexicana   (NCBI Taxonomy)   (Drugpedia)
Basic StructureLPG contains [PO4-->6Gal(β1-->4)Man(α1)] phosphosaccharide repeats linked to a conserved phosphosaccharide core and a conserved lyso alkylphosphatidylinositol residue. In contrast to L. donovani LPG, which exclusively contains the phosphodisaccharide repeats
BCSDB Structure2568
Proposed functionsN/A
Antigenic Nature used to produce antibodiesCon A binding proteins
Carrier NameNil
Conjugation MethodNil
AntibodiesMab AP3
Antibody type and classIgG1
Assay SystemELISA, immunoblotting
Cross-reactivityThis Mab cross-reacted with a highly glycosylated protein - acid phosphatase
Proposed epitopesThe epitope was proposed to consist of phosphosaccharide repeats or the sugar residues forming the cap at the non-reducing end
IEDB Epitope76720
Proposed UtilityThe epitopes recognized by this Mab have been localized in promastigotes and infected macrophages
Curator IDAA + AS
Date of Curation04-09-2010
References1721919


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