PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID1864
Carbohydrate NameCapsular polysaccharide   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
MicrobeNeisseria meningitidis Serogroup B   (NCBI Taxonomy)   (Drugpedia)
Basic StructureIt consists of a homopolymer of α(2-->8)-linked sialic acid residues
BCSDB Structure7487
Proposed functionsIt is an important virulence factor
Antigenic Nature used to produce antibodiesInfected patient
Carrier NameNil
Conjugation MethodNil
AntibodiesMab BES
Antibody type and classIgM
Assay SystemELISA, Rat protection assay
Cross-reactivityThis Mab cross-reacts with E. coli K1 polysaccharide but does not react with E. coli K92, group A and group C polysaccharides of Neisseria meningitidis. This Mab also reacts with N-propionylated group B polysaccharide
Proposed epitopesThe epitope consisted of α2-8 linked N-acetylneuraminic acid acid residues
IEDB EpitopeN/A
Proposed UtilityThis antibody protected infant rats from bacteremia caused by Escherichia coli K1
Curator IDAA + AS
Date of Curation18-11-2010
ReferencesPMC173242


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