| PolysacDB ID | 1178 |
| Carbohydrate Name | Lipoologosaccharide band B of the LPS (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Bordetella pertusis 134 LOS B variant strain (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | B. pertusis LPS is resolved electrophoretically into two bands, a slowly migrating band designated LOS A and a fast-migrating band designated LOS B. These two species differ in molecular weight as three N-acetyl amino sugars found on LOS A are not present on LOS B
|
| BCSDB Structure | N/A |
| Proposed functions | The LOS of B. pertussis exhibits biological activities similar to those of endotoxins from other gram-negative bacteria, including pyrogenicity, toxicity, induction of the Shwartzman reaction, induction of tumor necrosis factor production, and adjuvant properties |
| Antigenic Nature used to produce antibodies | N-Lauroyl sarcosine membrane extract (SME) from B. pertussis 9340 |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab BL-8 |
| Antibody type and class | IgM |
| Assay System | Antibody accessibility radioimmunobinding assay, Immunoblotting |
| Cross-reactivity | This Mab reacted with all B. pertussis and Bordetella bronchiseptica Vir- (avirulent) variant strains tested but is not present on Bordetella parapertussis and B. bronchiseptica Vir+ (virulent) wild-type strains |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | Moderate lytic activity against a mutant strain expressing only the LOS B band was observed with this Mab |
| Curator ID | AA + AS |
| Date of Curation | 27-02-2010
|
| References | PMC257226 |