PolysacDB ID | 1830 |
Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
Carbohydrate Class | Capsular polysaccharide |
Microbe | Neisseria meningitidis Serogroup C (NCBI Taxonomy) (Drugpedia) |
Basic Structure | It consists of a homopolymer of α(2-->9)-linked sialic acid residues. |
BCSDB Structure | 130704 |
Proposed functions | It is an important virulence factor |
Antigenic Nature used to produce antibodies | Glycoconjugates as well as purified capsular polysaccharide |
Carrier Name | Tetanus toxoid |
Conjugation Method | The oligosaccharide was activated using NaIO4 at 4°C for 60 min and combined with monomeric tetanus toxoid in sodium phosphate buffer containing NaBH3CN and heated at 37°C for 5 days |
Antibodies | Mab CP1050.20 |
Antibody type and class | IgG2b |
Assay System | ELISA |
Cross-reactivity | This Mab did not cross-react with the non-O-acetylated variant of capsular polysaccharide and also did not react with E. coli K92 capsular polysaccharide |
Proposed epitopes | N/A |
IEDB Epitope | N/A |
Proposed Utility | This Mab can be used for studying the capsular polysaccharide immunogenicity |
Curator ID | AA + AS |
Date of Curation | 10-11-2010
|
References | PMC97127 |