| PolysacDB ID | 1036 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor
|
| BCSDB Structure | 127448 |
| Proposed functions | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature used to produce antibodies | Whole killed mycobacteria leprae cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab Cs-35 |
| Antibody type and class | IgM |
| Assay System | Indirect and Competitive ELISA |
| Cross-reactivity | This antibody cross-reacted to M. tuberculosis and other Mycobacterium speices. |
| Proposed epitopes | β-D-Araf- (1-->2)-α-D-Araf-(1-->5)-α- D-Araf-(1-->5)-α-D-Araf within the branched hexa-Araf motif of mycobacterial arabinans |
| IEDB Epitope | 76797 |
| Proposed Utility | These antibodies could be used for screening of cell-wall mutants of mycobacteria lacking AG and AraLAM motifs and the recognition of biosynthetic intermediates of cell-wall polysaccharides unique to mycobacteria. |
| Curator ID | AA + AS |
| Date of Curation | 10-01-2010
|
| References | 12368438 |