| PolysacDB ID | 1165 |
| Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Bordetella pertusis 1414 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | B. pertusis LPS is resolved electrophoretically into two bands, a slowly migrating band designated LOS A and a fast-migrating band designated LOS B. These two species differ in molecular weight as three N-acetyl amino sugars found on LOS A are not present on LOS B
|
| BCSDB Structure | N/A |
| Proposed functions | The LOS of B. pertussis exhibits biological activities similar to those of endotoxins from other gram-negative bacteria, including pyrogenicity, toxicity, induction of the Shwartzman reaction, induction of tumor necrosis factor production, and adjuvant properties |
| Antigenic Nature used to produce antibodies | B. pertusis LPS |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab D7 |
| Antibody type and class | IgG3 |
| Assay System | ELISA and Immunostaining |
| Cross-reactivity | Did not cross-react with the B. pertusis variant strain A101 |
| Proposed epitopes | The epitope recognized by D7 is affected by the addition of the O-side chain and that a portion of the distal trisaccharide could be involved in this epitope. This suggests therefore that this epitope may consist of the FucN(Ac)Me-->GlcN disaccharide |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be useful for rapid typing of Bordetella in clinical isolates and can be used to detect antigenic modifications in LPSs from variant B. pertassis strains, or from related Bordetella species (B. parapertassis, B. bronchiseptica |
| Curator ID | AA + AS |
| Date of Curation | 24-02-2010
|
| References | 8936324 |