| PolysacDB ID | 2423 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Streptococcus Group B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | The structure of type III polysaccharide is as follows : -3-β-D-Galp-(1-->4)-β-D-Glcp-(1-->6)-β-D-GlcNAcp-(1--> along with the fact that the carboxyl of the -D-NeuNAcp was linked to the O-3 of the adjacent D-galactose to form the type-specific site
|
| BCSDB Structure | N/A |
| Proposed functions | The property of invasiveness is related to the anti-phagocytic properties conferred to Group B Streptococcus by its capsular polysaccharide |
| Antigenic Nature used to produce antibodies | Whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab GBS II/4-1OBA9 |
| Antibody type and class | N/A |
| Assay System | Counterimmunoelectrophoresis, Radioactive binding assay, Ouchterlony double-diffusion, Latex particle agglutination tests |
| Cross-reactivity | A9 antibody cross-reacted with group B antigen in gel diffusion reactions with extracts of Lancefield group A, B, C, D, F, and G streptococci |
| Proposed epitopes | Rhamnose is not an immunodominant determinant contrasts with polyclonal rabbit antiserum to this antigen |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab was a highly sensitive reagent in detecting soluble group B antigen by counterimmunoelectrophoresis. A9 antibody-coated latex particles were compared with a commercially available polyclonal latex agglutination reagent and shown to be equally sensitive and specific in the detection of soluble group B antigen in urine and cerebrospinal fluid from patients with GBS infections |
| Curator ID | AA + AS |
| Date of Curation | 08-05-2011
|
| References | PMC272311 |