PolysacDB ID | 2551 |
Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
Carbohydrate Class | Lipopolysaccharide |
Microbe | Vibrio cholerae 01 35 Inaba (NCBI Taxonomy) (Drugpedia) |
Basic Structure | It is a linear unbranched homopolymer of 1,6-linked-D-galactopyranosyl residues. |
BCSDB Structure | N/A |
Proposed functions | V. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera |
Antigenic Nature used to produce antibodies | Purified LPS |
Carrier Name | Nil |
Conjugation Method | Nil |
Antibodies | Mab H4 |
Antibody type and class | IgM |
Assay System | Enzyme-linked immunosorbent assay inhibition experiments |
Cross-reactivity | This Mab reacted with Ogawa 34 and Inaba 35 serotype LPS but did not react with O2 LPS |
Proposed epitopes | This Mab was specific to A antigen. Epitope A was postulated to be either the perosamine residues or the N-tetronic acid (N-3-deoxy-L-glycero-tetronic acid) side chain |
IEDB Epitope | N/A |
Proposed Utility | This Mab had a good agglutinating capacity when tested against V. cholerae 0:1 strains |
Curator ID | AA + AS |
Date of Curation | 24-06-2011
|
References | PMC270838 |