PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID1844
Carbohydrate NameCapsular polysaccharide   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
MicrobeEscherichia coli K1 strain   (NCBI Taxonomy)   (Drugpedia)
Basic StructureIt consists of a homopolymer of α(2-->8)-linked sialic acid residues
BCSDB Structure6824
Proposed functionsIt is an important virulence factor
Antigenic Nature used to produce antibodiesWhole cells
Carrier NameNil
Conjugation MethodNil
AntibodiesMab HmenB13
Antibody type and classIgM
Assay SystemELISA, flow cytometry and bactericidal assay
Cross-reactivityThis Mab cross-reacted with Neisseria meningitidis Group B capsular polysaccharide and EV36 which is an E. coli K-12 strain possessing the genes for K1 capsular polysaccharide production and expresses non-acetylated α (2-->8) polysaccharide just like Neisseria meningitidis group B capsular polysaccharide
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab readily killed group B meningococci in the presence of rabbit complement
Curator IDAA + AS
Date of Curation13-11-2010
ReferencesPMC98292


Bioinformatics Centre, Institute of Microbial Technology, Sec - 39A, Chandigarh, India - 160036