PolysacDB ID | 1844 |
Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
Carbohydrate Class | Capsular polysaccharide |
Microbe | Escherichia coli K1 strain (NCBI Taxonomy) (Drugpedia) |
Basic Structure | It consists of a homopolymer of α(2-->8)-linked sialic acid residues
|
BCSDB Structure | 6824 |
Proposed functions | It is an important virulence factor |
Antigenic Nature used to produce antibodies | Whole cells |
Carrier Name | Nil |
Conjugation Method | Nil |
Antibodies | Mab HmenB13 |
Antibody type and class | IgM |
Assay System | ELISA, flow cytometry and bactericidal assay |
Cross-reactivity | This Mab cross-reacted with Neisseria meningitidis Group B capsular polysaccharide and EV36 which is an E. coli K-12 strain possessing the genes for K1 capsular polysaccharide production and expresses non-acetylated α (2-->8) polysaccharide just like Neisseria meningitidis group B capsular polysaccharide |
Proposed epitopes | N/A |
IEDB Epitope | N/A |
Proposed Utility | This Mab readily killed group B meningococci in the presence of rabbit complement |
Curator ID | AA + AS |
Date of Curation | 13-11-2010
|
References | PMC98292 |