PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID2517
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeVibrio cholerae 01 serogroup Inaba strain X19203   (NCBI Taxonomy)   (Drugpedia)
Basic StructureIt is a linear unbranched homopolymer of 1,6-linked-D-galactopyranosyl residues.
BCSDB StructureN/A
Proposed functionsV. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera
Antigenic Nature used to produce antibodiesKilled cells
Carrier NameNil
Conjugation MethodNil
AntibodiesMab IH 4
Antibody type and classIgG3
Assay SystemSlide agglutination, microdilution agglutination, and passive hemagglutination tests
Cross-reactivityThis Mab showed almost identical reactivities to both the Ogawa- and the Inaba-type cells
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab will be a very useful tool for resolution of the antigenic structure of V. cholerae 01, especially the Inaba-specific determinant
Curator IDAA + AS
Date of Curation15-06-2011
ReferencesPMC266894


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