PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

Home | Search | Advance Search | Browse | Online Submission | Documentation & FAQ | Team | Contact us

Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID2521
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeVibrio cholerae 01 serogroup Inaba strain X19203   (NCBI Taxonomy)   (Drugpedia)
Basic StructureIt is a linear unbranched homopolymer of 1,6-linked-D-galactopyranosyl residues.
BCSDB StructureN/A
Proposed functionsV. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera
Antigenic Nature used to produce antibodiesKilled cells
Carrier NameNil
Conjugation MethodNil
AntibodiesMab IH 8
Antibody type and classIgG3
Assay SystemSlide agglutination, microdilution agglutination, and passive hemagglutination tests
Cross-reactivityThis Mab reacted to Inaba-type cells but only very weakly reacted to Ogawa-type cells
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab will be a very useful tool for resolution of the antigenic structure of V. cholerae 01, especially the Inaba-specific determinant. Moreover, highly Inaba specific antibodies will be able to be used in the identification of Inaba serotypes instead of polyclonal Inaba-specific antisera
Curator IDAA + AS
Date of Curation16-06-2011
ReferencesPMC266894


Bioinformatics Centre, Institute of Microbial Technology, Sec - 39A, Chandigarh, India - 160036