PolysacDB ID | 2035 |
Carbohydrate Name | Core oligosaccharide (Drugpedia) |
Carbohydrate Class | Lipopolysaccharide |
Microbe | Pseudomonas aeruginosa (NCBI Taxonomy) (Drugpedia) |
Basic Structure | The LPS consists of three regions, namely O-polysaccharide, core oligosaccharide and lipid A. The core region of LPS is divided into the outer core and inner core. The inner core region consists of 2-keto-3-deoxyoctonic acid (KDO), heptose, phosphate, and probably ethanolamine. The outer core region commonly contains D-glucose, L-rhamnose, D-galactosamine, and L-alanine. The O-antigens consist of a trisaccharide repeating unit which consists of two uronic acid derivatives and one N-acetyl fucosamine residue
|
BCSDB Structure | N/A |
Proposed functions | N/A |
Antigenic Nature used to produce antibodies | Formalin killed whole cells |
Carrier Name | Nil |
Conjugation Method | Nil |
Antibodies | Mab KN-2B11 |
Antibody type and class | IgM |
Assay System | Competitive enzyme immunoassay, ELISA, immunoblotting |
Cross-reactivity | "This MAb specifically bound to clinical isolates belonging to Homma serotypes A, F, G and K at a frequency of 70 to 86% and to serotypes H and M isolates at about 50%. They did not bind to any isolates of serotype B, E, and I tested." |
Proposed epitopes | α-L-rhamnose residues in the outer core of LPS might be the part of the epitope. |
IEDB Epitope | N/A |
Proposed Utility | This Mab agglutinated P. aeruginosa cells |
Curator ID | AA + AS |
Date of Curation | 23-12-2010
|
References | PMC313341 |