PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID2299
Carbohydrate NameCore oligosaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeCampylobacter fetus   (NCBI Taxonomy)   (Drugpedia)
Basic StructureThe LPS molecule of C. fetus is composed of three distinct structural domains: a hydrophobic lipid A portion which forms the outer leaflet of the outer membrane and which contains the endotoxic activity, a low-molecular-weight oligosaccharide core complex, and a variable-length O-specific polysaccharide chain with repeating oligosaccharide units (O-antigen)
BCSDB StructureN/A
Proposed functionsThe LPS O-antigens are the basis of the C. fetus heat-stable serotyping Scheme
Antigenic Nature used to produce antibodiesWhole cells
Carrier NameNil
Conjugation MethodNil
AntibodiesMab M1357
Antibody type and classN/A
Assay SystemELISA and immunoblotting
Cross-reactivityThis Mab was highly specific tp C. fetus strains and reacted with serotype A and B strains
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityDue to its high specificity, this Mab is potentially useful as immunodiagnostic reagent for detection, identification and characterization of C. fetus
Curator IDAA + AS
Date of Curation25-03-2011
References12079745


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