| PolysacDB ID | 2288 |
| Carbohydrate Name | O-polysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Shigella flexneri serotype 5 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Chemically, the O-antigen is a polysaccharide chain of variable length, built up by repetitive sequences of tetra- to hexasaccharides. It consists of a basic tetrasaccharide repeating unit consisting of three rhamnoses and one N-acetylglucosamine was common to all S. flexneri strains (except serotype 17): -2)-α-L-Rhap-(1-->2)-α-L-Rhap-(1-->3)-α-L-Rhap-(1-->3)-β-D-GlcpNAc-(1-->
|
| BCSDB Structure | N/A |
| Proposed functions | LPS plays an important virulence role based on its antiphagocytic and endotoxic properties |
| Antigenic Nature used to produce antibodies | Whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab MASF V-3 |
| Antibody type and class | IgM |
| Assay System | ELISA |
| Cross-reactivity | This Mab's reactivity was exclusive for S. flexneri 5a and 5b LPS |
| Proposed epitopes | α-D-Glc-(1-->3)-α-L-rhamnosyl residues seemed to be the part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab may prove to be valuable reagents in the studies of protective immunity against Shigella bacteria |
| Curator ID | AA + AS |
| Date of Curation | 20-03-2011
|
| References | 2437036 |