PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID2230
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeSalmonella typhimurium SL 1102 [Re]   (NCBI Taxonomy)   (Drugpedia)
Basic StructureLPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain
BCSDB StructureN/A
Proposed functionsLPS plays an important virulence role based on its antiphagocytic and endotoxic properties
Antigenic Nature used to produce antibodiesHeat killed bacteria
Carrier NameNil
Conjugation MethodNil
AntibodiesMab MAST5
Antibody type and classIgG3
Assay SystemEnzyme immunoassay
Cross-reactivityThis Mab cross-reacted with Rd2 LPS
Proposed epitopes3-deoxy-D-mannooctulosonic acid [KDO] residues at the terminal non-reducing ends seemed to be the part of the epitope. The particular epitope was proposed to be α-Kdo[2-->4] Kdo
IEDB EpitopeN/A
Proposed UtilityThis Mab would help elucidate the Kdo LPS domain structure
Curator IDAA + AS
Date of Curation14-03-2011
References2033255


Bioinformatics Centre, Institute of Microbial Technology, Sec - 39A, Chandigarh, India - 160036