PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID2215
Carbohydrate NameCapsular Vi polysaccharide   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
MicrobeSalmonella typhi   (NCBI Taxonomy)   (Drugpedia)
Basic StructureThe salmonella Vi Capsular polysaccharide is a linear homopolymer of α[1-->4]-O-acetyl-N-acetyl-galactosaminuronic acid
BCSDB Structure3149
Proposed functionsIt is an important virulence factor. The Vi capsule shields the bacteria against phagocytosis by its surface negative charge properties and by covering cell-envelope components sensitive to serum opsonins
Antigenic Nature used to produce antibodiesHeat killed bacteria and purified Vi polysaccharide
Carrier NameNil
Conjugation MethodNil
AntibodiesMab MATy-V9
Antibody type and classIgM
Assay SystemInhibition enzyme immunoassay
Cross-reactivityThis Mab was specific to Vi antigen
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab was shown to be a useful serotyping agent by correct identification in slide agglutination tests of 32 clinical isolates of all the S. typhi and other serogroup D salmonellae among a total of 140 bacterial isolates representing eight different Enterobacteriaceae genera tested
Curator IDAA + AS
Date of Curation08-03-2011
References1426999


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