PolysacDB ID | 2041 |
Carbohydrate Name | O-polysaccharide (Drugpedia) |
Carbohydrate Class | Lipopolysaccharide |
Microbe | Pseudomonas aeruginosa Serotype O5 (NCBI Taxonomy) (Drugpedia) |
Basic Structure | The LPS consists of three regions, namely O-polysaccharide, core oligosaccharide and lipid A. The core region of LPS is divided into the outer core and inner core. The inner core region consists of 2-keto-3-deoxyoctonic acid (KDO), heptose, phosphate, and probably ethanolamine. The outer core region commonly contains D-glucose, L-rhamnose, D-galactosamine, and L-alanine. The O-antigens consist of a trisaccharide repeating unit which consists of two uronic acid derivatives and one N-acetyl fucosamine residue
|
BCSDB Structure | 1672 |
Proposed functions | N/A |
Antigenic Nature used to produce antibodies | Formalin killed whole cells |
Carrier Name | Nil |
Conjugation Method | Nil |
Antibodies | Mab MF15-4 |
Antibody type and class | IgM |
Assay System | ELISA, immunoblotting, ouchterlony immunodiffusion |
Cross-reactivity | This Mab was specific to serotype O5 |
Proposed epitopes | The epitope consisted of N-acetyl fucosamine residues with an αglycosidic linkage and a minimum of six O repeats of serotype O5 polysaccharide |
IEDB Epitope | N/A |
Proposed Utility | This Mab helps us shed some light on the nature of O-specific and common epitopes in the LPS of P. aeruginosa |
Curator ID | AA + AS |
Date of Curation | 26-12-2010
|
References | PMC205836 |