PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID2170
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeSalmonella typhimurium   (NCBI Taxonomy)   (Drugpedia)
Basic StructureLPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The O-antigen part consists of the following residues : -2)-α-D-Manp [branched to α-Abep-(1-->3)] -(1-->4)-α-L-Rhap-(1-->3)-α-D-Galp-(1-
BCSDB Structure124341
Proposed functionsLPS plays an important virulence role based on its antiphagocytic and endotoxic properties
Antigenic Nature used to produce antibodiesWhole cells
Carrier NameNil
Conjugation MethodNil
AntibodiesMab MO4-3
Antibody type and classIgG3
Assay SystemELISA, immunoblotting
Cross-reactivityThis Mab was also specific but cross-reacted with Salmonella paratyphi serogroup A
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab can be used as a serotyping reagent for the identification of serogroup B salmonellae in a routine diagnostic bacteriology laboratory
Curator IDAA + AS
Date of Curation19-02-2011
ReferencesPMC270232


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