| PolysacDB ID | 1610 |
| Carbohydrate Name | N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a homopolymer of α(2-->8) sialic acid
|
| BCSDB Structure | N/A |
| Proposed functions | This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins |
| Antigenic Nature used to produce antibodies | A patient suffering from IgM lambda monoclonal gammopathy |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab NOV |
| Antibody type and class | IgM |
| Assay System | Ouchterlony Gel Diffusion, ELISA, invivo protection assays |
| Cross-reactivity | This Mab reacted with group B meningococcal and E. coli K1 capsular polysaccharides and did not react with a(2 --> 9)-linked poly-N-acetylneuraminic acid, the capsular polysaccharide of the group C meningococcus, nor with the capsular polysaccharide of E. coli K92 or K100. It also crossreacts with polynucleotides and denatured DNA |
| Proposed epitopes | The epitope was proposed to consist of α(2-->8)-linked poly-N-acetylneuraminic acid |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab is protective against E. coli in newborn rats |
| Curator ID | AA + AS |
| Date of Curation | 22-09-2010
|
| References | PMC2188242 |