| PolysacDB ID | 1516 |
| Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Klebsiella pneumoniae Friedlander 201 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | O-1 side chain of the LPS is proposed to contain a disaccharide repeat unit consisting of [-α-D-Galp-(1->3)-β-D-Galf-] (1->4), where Gal is galactose
|
| BCSDB Structure | N/A |
| Proposed functions | These major cell surface antigens play important roles in the ability of the bacterium to evade host cell defenses |
| Antigenic Nature used to produce antibodies | Formalinized whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab Ru-O1 |
| Antibody type and class | IgG2b |
| Assay System | ELISA and invivo protection studies |
| Cross-reactivity | This Mab cross-reacted with LPS prepared from strains belonging to the O1 serogroup, O19b antigen of E. coli, which has been shown to be immunologically identical to Klebsiella O1 and O6 and O8 antigens |
| Proposed epitopes | O1 antigen seems to bea part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab showed invivo protection and significantly reduced bacterial dissemination to various organs as well as macroscopic and histologic pulmonary alterations |
| Curator ID | AA + AS |
| Date of Curation | 09-08-2010
|
| References | PMC175211 |