PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID1127
Carbohydrate NameCA antigen   (Drugpedia)
Carbohydrate ClassGlycoprotein
MicrobeAspergillus fumigatus 2085   (NCBI Taxonomy)   (Drugpedia)
Basic StructureGalactomannans are composed of an α-1,6-linked mannan backbone substituted with mannopyranose oligosaccharides and immunodominant terminal galactofuranose present either singly or linked to oligogalactosides
BCSDB StructureN/A
Proposed functionsThe wide distribution and similar chemical structure of the galactomannans have been responsible for serologic cross-reactions
Antigenic Nature used to produce antibodiesCell walls of A. fumigatus 2085
Carrier NameNil
Conjugation MethodNil
AntibodiesMab SC1
Antibody type and classIgM
Assay SystemEnzyme Immunoassay, Precipitin reactions, Immunoblotting, Immunofluorescence assays
Cross-reactivityMAb SC1 was reactive with other Aspergillus species, Fusarium sp., and dermatophytes
Proposed epitopesGalactomannan residues seemed to be the part of immunodominant region
IEDB EpitopeN/A
Proposed UtilityThese MAbs will be useful as immunoprobes for studying epitopes responsible for the shared antigenicity of fungal mannans and galactomannans and for examining their expression during hyphal and conidial morphogenesis
Curator IDAA + AS
Date of Curation07-02-2010
ReferencesPMC258783


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