PolysacDB ID | 1127 |
Carbohydrate Name | CA antigen (Drugpedia) |
Carbohydrate Class | Glycoprotein |
Microbe | Aspergillus fumigatus 2085 (NCBI Taxonomy) (Drugpedia) |
Basic Structure | Galactomannans are composed of an α-1,6-linked mannan backbone substituted with mannopyranose oligosaccharides and immunodominant terminal galactofuranose present either singly or linked to oligogalactosides
|
BCSDB Structure | N/A |
Proposed functions | The wide distribution and similar chemical structure of the galactomannans have been responsible for serologic cross-reactions |
Antigenic Nature used to produce antibodies | Cell walls of A. fumigatus 2085 |
Carrier Name | Nil |
Conjugation Method | Nil |
Antibodies | Mab SC1 |
Antibody type and class | IgM |
Assay System | Enzyme Immunoassay, Precipitin reactions, Immunoblotting, Immunofluorescence assays |
Cross-reactivity | MAb SC1 was reactive with other Aspergillus species, Fusarium sp., and dermatophytes |
Proposed epitopes | Galactomannan residues seemed to be the part of immunodominant region |
IEDB Epitope | N/A |
Proposed Utility | These MAbs will be useful as immunoprobes for studying epitopes responsible for the shared antigenicity of fungal mannans and galactomannans and for examining their expression during hyphal and conidial morphogenesis |
Curator ID | AA + AS |
Date of Curation | 07-02-2010
|
References | PMC258783 |