PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID1258
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeCampylobacter jejuni serotype O:41 strains   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed functionsN/A
Antigenic Nature used to produce antibodiesPatients infected with Campylobacter jejuni serotype O:41 strains
Carrier NameNil
Conjugation MethodNil
AntibodiesMab WO1-4
Antibody type and classIgM
Assay SystemImmunoblotting
Cross-reactivityThis antibody reacted with 3 of the 4 serotype O:41 strains but did not cross-react with LPS of other Campylobacter jejuni strains. Also cross-reacted with human GM1 ganglioside
Proposed epitopesThis Mab binds the terminal dissacharide Galβ1-->3GalNAc
IEDB EpitopeN/A
Proposed UtilityThis Mab will help in the unveiling of the mechanisms of molecular mimicry exhibited by campylobacter LPS with human ganglioside and its functional significance in the disease progression
Curator IDAA + AS
Date of Curation28-04-2010
ReferencesPMC116569


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