PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID2445
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeShigella flexneri serotype Y   (NCBI Taxonomy)   (Drugpedia)
Basic StructureLPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The O-antigen part consists of the following residues : -3)-α-D-GlcpNAc-(1-->3)-β-L-Rhap-(1-->2)-α-L-Rhap-(1-->2)-β-L-Rhap-(1-
BCSDB Structure113249
Proposed functionsLPS plays an important virulence role based on its antiphagocytic and endotoxic properties
Antigenic Nature used to produce antibodiesPhenol killed cells
Carrier NameNil
Conjugation MethodNil
AntibodiesMab Y-B5
Antibody type and classIgM
Assay SystemELISA, immunodiffusion
Cross-reactivityThis Mab was highly cross-reactive and cross-reacted with 1b, 2b, 3a, 4a and X LPS
Proposed epitopesThis Mab reacted with alkali-treated LPS
IEDB Epitope76696
Proposed UtilityThis Mab can be used for antigenic characterization of Shigella LPS
Curator IDAA + AS
Date of Curation16-05-2011
References3531329


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