PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID1033
Carbohydrate NameLipoarabinomannan   (Drugpedia)
Carbohydrate ClassGlycolipid
MicrobeMycobacterium leprae   (NCBI Taxonomy)   (Drugpedia)
Basic StructureMycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor
BCSDB Structure127448
Proposed functionsT cell proliferation and to interfere with gamma interferon-mediated activation of macrophages
Antigenic Nature used to produce antibodiesWhole killed mycobacteria leprae cells
Carrier NameNil
Conjugation MethodNil
AntibodiesMab lam204
Antibody type and classIgM
Assay SystemSandwich ELISA
Cross-reactivityThis antibody cross-reacted with cross-reacted to a large number of mycobacterial species such as M. tuberculosis, M. bovis, M leprae, M. phlei and M. avium
Proposed epitopesN\A
IEDB EpitopeN/A
Proposed UtilityThese antibodies could be used to detect mycobacterial antigens in sputum
Curator IDAA + AS
Date of Curation09-01-2010
References2127645


Bioinformatics Centre, Institute of Microbial Technology, Sec - 39A, Chandigarh, India - 160036