| PolysacDB ID | 2312 |
| Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Shigella flexneri serotype 5a (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Chemically, the O-antigen is a polysaccharide chain of variable length, built up by repetitive sequences of tetra- to hexasaccharides. It consists of a basic tetrasaccharide repeating unit consisting of three rhamnoses and one N-acetylglucosamine was common to all S. flexneri strains (except serotype 17): -2)-α-L-Rhap-(1-->2)-α-L-Rhap-[branched to α-D-Glcp(1-->3)](1-->3)-α-L-Rhap-(1-->3)-β-D-GlcpNAc-(1--> |
| BCSDB Structure | 108654 |
| Proposed functions | LPS plays an important virulence role based on its antiphagocytic and endotoxic properties |
| Antigenic Nature used to produce antibodies | Whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | MIgA |
| Antibody type and class | IgA |
| Assay System | ELISA, In Vivo Protection Experiments |
| Cross-reactivity | The antibody recognized 5a LPS but failed to react with 2a LPS and Y LPS |
| Proposed epitopes | MlgA was directed against a serotype specific epitope comprising at least the glucosyl residue specifically linked to the central rhamnose of the basic structure of the S. flexneri LPS |
| IEDB Epitope | 76703 |
| Proposed Utility | This Mab protected the animals against subsequent intranasal challenge with S. flexneri serotype 5a |
| Curator ID | AA + AS |
| Date of Curation | 30-03-2011
|
| References | PMC2192169 |