| PolysacDB ID | 1010 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium tuberculosis (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues, and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor
|
| BCSDB Structure | 127448
|
| Proposed functions | Reported to suppress T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages. Other reported effects include inhibition of protein kinases, inhibition of the synthesis of mRNA encoding IL-2, IL-5, and granulocyte-macrophage colony stimulating factor (GM-CSF) in human T cells and activation of the complement cascade |
| Antigenic Nature used to produce antibodies | Heat killed Mycobacterium tuberculosis |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | SMITB14 |
| Antibody type and class | IgG1 |
| Assay System | N\A |
| Cross-reactivity | SMITB14 bound to whole M. tuberculosis bacteria (H37Rv and Harlingen strains) as well as to the attenuated BCG, but not to other species such as Escherichia coli strains of various O serotypes, Streptococcus pneumoniae isolates, strains of Salmonella, Yersinia enterocolitica and Y. pseudotuberculosis and Nocardia sp. |
| Proposed epitopes | Arabinomannan portion of the antigen |
| IEDB Epitope | N/A |
| Proposed Utility | This antibody might be involved in blocking of mycobacterial invasion. SMITB14 may prevent the uptake of M. tuberculosis through receptor(s) that facilitate bacterial survival and growth. |
| Curator ID | AA + AS |
| Date of Curation | 03-01-2010
|
| References | PMC1809178 |