| PolysacDB ID | 1013 |
| Carbohydrate Name | Glucurunoxylomannan (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Cryptococcus neoformans serotype A (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | The GXM backbone consists of a linear α(1-->3)-linked mannan substituted at 2-O positions by single residues of either xylose or glucuronic acid
|
| BCSDB Structure | 116826
|
| Proposed functions | Antiphagocytic ; an important virulence factor |
| Antigenic Nature used to produce antibodies | Pure Capsular polysaccharide |
| Carrier Name | N/A |
| Conjugation Method | N/A |
| Antibodies | Mab E1 |
| Antibody type and class | IgG1 |
| Assay System | Agglutination with C. neoformans serotype A cells, Radial immunodiffusion, Indirect Immunofluorescence,, ELISA, Competitive binding assays |
| Cross-reactivity | This antibody was highly specific to serotype A, low levels of cross reactivity to serotypes B and D. Among the other yeasts tested, a cross-reaction was only detected with Trichosporon beigelii. |
| Proposed epitopes | N\A |
| IEDB Epitope | 115576 |
| Proposed Utility | Could be useful for fundamental studies on the glucuronoxylomannan structure, as well as for clinical applications such as serotyping and possibly the serological diagnosis of cryptococcosis |
| Curator ID | AA + AS |
| Date of Curation | 04-01-2010
|
| References | PMC260404 |