| PolysacDB ID | 1015 |
| Carbohydrate Name | Beta-glucan (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Candida albicans (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Glucans are a heterogeneous group of glucose polymers, consisting of a backbone of β(1-->3)-linked β-D-glucopyranosyl units with β(1-->6)-linked side chains of varying distribution and length
|
| BCSDB Structure | 125281
|
| Proposed functions | Glucan is an essential cell wall component in pathogenic fungi and plays a critical role in cell viability |
| Antigenic Nature used to produce antibodies | Glycoconjugates |
| Carrier Name | Diphtheria toxoid CRM 197 |
| Conjugation Method | A 20-fold molar excess of activated polysaccharide was reacted overnight with the protein, at room temperature, in 10 mM phosphate buffer, pH 7.2. The unbound polysaccharide was separated from the glyco-conjugate by ultrafiltration, using Amicon 10-kD filter devices |
| Antibodies | Polysera |
| Antibody type and class | IgG |
| Assay System | Invivo protection assays, growth inhibition assays, indirect ELISA |
| Cross-reactivity | N/A |
| Proposed epitopes | N\A |
| IEDB Epitope | 76671 |
| Proposed Utility | The Lam-CRM conjugate is immunogenic and protective against systemic candidiasis in mice. The antibodies induce passive protection in mice against systemic and mucosal candidiasis |
| Curator ID | AA + AS |
| Date of Curation | 04-01-2010
|
| References | PMC2212864 |