PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID1038
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeRhizobium leguminosarum   (NCBI Taxonomy)   (Drugpedia)
Basic StructureLPS is composed of three parts: (1) lipid A, (2) core polysaccharide, and (3) O antigen. The lipid A region contains two glucosamine sugar derivatives, each with three fatty acids and phosphate or pyrophosphate attached. The core polysaccharide has KDO and attached to lipid A. The side chain O is small polysaccharide chain extending outward from the core, it has several peculiar sugars and varies in composition between bacterial strains.
BCSDB Structure1686
Proposed functionsLPS is most unusual constituents of outer membrane. It plays important role in host defence avoidance. LPS contributes to the negative charge of the bacterial surface. Lipid A is often toxic and act as endotoxin
Antigenic Nature used to produce antibodiesMixture of suspension of cell envelop.
Carrier NameNil
Conjugation MethodNil
AntibodiesMab 3
Antibody type and classN\A
Assay SystemWestern blotting, spot imunoassays, agglutination tests
Cross-reactivityThis antibody was cross-reactive with different strains of R.leguminosarum like R.biovars viciae, trifolli and phaseoli.
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityN\A
Curator IDAA + AS
Date of Curation10-01-2010
ReferencesPMC209711


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