PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID1464
Carbohydrate NameCapsular polysaccharide   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
MicrobeEnterococcus faecalis 12030   (NCBI Taxonomy)   (Drugpedia)
Basic StructureGlycerol teichoic acid-like molecules with a carbohydrate backbone structure of 6-α-D-glucose- 1-->2 glycerol-3-PO4 with substitution on carbon 2 of the glucose with an α-2-1-D-glucose residue
BCSDB Structure2446
Proposed functionsThese polysaccharides are major virulence factors
Antigenic Nature used to produce antibodiesGentamicin-killed Enterococcus faecalis strains
Carrier NameNil
Conjugation MethodNil
AntibodiesPolysera
Antibody type and classN/A
Assay SystemOpsonophagocytic assay, immunoelectron microscopy
Cross-reactivityThis antisera reacted with the homologous strain (12030) and mediated opsonic killing of 33% of all strains tested. In addition, this serum killed two (28%) of seven vancomycin-resistant Enterococcus faecium strains
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis antisera was opsonophagcytic
Curator IDAA + AS
Date of Curation24-07-2010
References10024563


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