PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID1513
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeKlebsiella strains KD2   (NCBI Taxonomy)   (Drugpedia)
Basic StructureO-1 side chain of the LPS is proposed to contain a disaccharide repeat unit consisting of [-α-D-Galp-(1->3)-β-D-Galf-] (1->4), where Gal is galactose
BCSDB StructureN/A
Proposed functionsThese major cell surface antigens play important roles in the ability of the bacterium to evade host cell defenses
Antigenic Nature used to produce antibodiesFormalinized whole cells
Carrier NameNil
Conjugation MethodNil
AntibodiesPolysera
Antibody type and classN/A
Assay SystemELISA and immunoblotting
Cross-reactivityThe antisera reacted most strongly against the HMW-LPS fraction of Kliebsiella strain KD2 but also recognized the LMW-LPS of KLebsiella strains KD37 and KD2
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis antibody may help in the stuctural and functional elucidation of O1 side chain of Klebsiella LPS
Curator IDAA + AS
Date of Curation09-08-2010
ReferencesPMC259910


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