PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID1761
Carbohydrate NamePeptide mimotope   (Drugpedia)
Carbohydrate ClassGlycoprotein
MicrobeMycobacterium tuberculosis   (NCBI Taxonomy)   (Drugpedia)
Basic StructureThe peptide consisted of the following sequence : QEPLMGTVPIRAGGGS
BCSDB StructureN/A
Proposed functionsN/A
Antigenic Nature used to produce antibodiesPurified peptide
Carrier NameNil
Conjugation MethodNil
AntibodiesPolysera
Antibody type and classN/A
Assay SystemELISA, immunoblotting
Cross-reactivityThis antisera recognized mannosylated Mycobacterium tuberculosis cell-wall antigens arabinomannan, lipoarabinomannan and the glycosylated recombinant protein Apa. The antisera also cross-reacted with mannans from Saccharomyces cerevisiae, but did not react with phosphatidyl-inositol-di-mannoside or arabinogalactan from Mycobacteria
Proposed epitopesThe epitope was proposed to be oligomannosidic in nature
IEDB EpitopeN/A
Proposed UtilityThis peptide mimotope can used as surrogate reagent for immunodiagnosis of tuberculosis
Curator IDAA + AS
Date of Curation24-10-2010
ReferencesPMC1134969


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