PolysacDB ID | 1807 |
Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
Carbohydrate Class | Capsular polysaccharide |
Microbe | Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia) |
Basic Structure | It consists of a homopolymer of α(2-->8)-linked sialic acid residues
|
BCSDB Structure | 7487
|
Proposed functions | It is an important virulence factor |
Antigenic Nature used to produce antibodies | Whole cells |
Carrier Name | Nil |
Conjugation Method | Nil |
Antibodies | Mab 30H12 |
Antibody type and class | IgG2a |
Assay System | ELISA and bactericidal assays |
Cross-reactivity | This Mab was specifc to Neisseria meningitidis group B and did not cross-react with group A and group C N. meningitidis capsular polysaccharides. This Mab did not recognized N-propionylated capsular polysaccharide of group B meningitidis |
Proposed epitopes | α[2-->8] linked N-acetyl neuraminic acid residues seemed to be the part of the epitope |
IEDB Epitope | N/A |
Proposed Utility | This Mab had potent bactericidal activity |
Curator ID | AA + AS |
Date of Curation | 05-11-2010
|
References | 1284118 |