PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID2267
Carbohydrate NameY O-polysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeShigella flexneri   (NCBI Taxonomy)   (Drugpedia)
Basic StructureThe O-LPS consists of a tetrasaccharide repeating unit α-L-Rhap-(1-->2)-α-L-Rhap(1-->3)- . This tetrasaccharide is polymerized and joined by β-1,2 linkages between N-acetyl-D-glucosamine and L-rhamnosyl to form the O-polysaccharide chain
BCSDB StructureN/A
Proposed functionsN/A
Antigenic Nature used to produce antibodiesHeat-killed S. flexnerf bacteria serotype Y
Carrier NameNil
Conjugation MethodNil
AntibodiesMab MASF Y-3
Antibody type and classN/A
Assay SystemELISA, FARR assay
Cross-reactivityMASF Y-3 bound to LPS of serotypes 2a. 3b. 4b. And Y
Proposed epitopesThe terminal nonreducing end of the O-polysaccharide complementary to the tetrasaccharide repeating unit
IEDB Epitope76696
Proposed UtilityThis Mab would help in the delineation of the antigenic stucture of Y O polysaccharide
Curator IDAA + AS
Date of Curation15-03-2011
References2438343


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