| PolysacDB ID | 2325 |
| Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Shigella flexneri [polyvalent S. flexneri 2a/3a vaccine (CVD 1207/CVD 1211)] (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Chemically, the O-antigen is a polysaccharide chain of variable length, built up by repetitive sequences of tetra- to hexasaccharides. It consists of a basic tetrasaccharide repeating unit consisting of three rhamnoses and one N-acetylglucosamine was common to all S. flexneri strains (except serotype 17): -2)-α-L-Rhap-(1-->2)-α-L-Rhap-(1-->3)-α-L-Rhap-(1-->3)-β-D-GlcpNAc-(1-->
|
| BCSDB Structure | N/A |
| Proposed functions | LPS plays an important virulence role based on its antiphagocytic and endotoxic properties |
| Antigenic Nature used to produce antibodies | Heat killed cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Antisera |
| Antibody type and class | IgA |
| Assay System | ELISA |
| Cross-reactivity | This antisera showed an extensive cross-reaction that included S. flexneri serotypes 1a, 1b, 2b, 4b, 5b, and Y |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | Cross-protection was observed among S. flexneri serotypes elicited by the S. flexneri 2a/3a vaccine |
| Curator ID | AA + AS |
| Date of Curation | 02-04-2011
|
| References | PMC96386 |