PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 5

Entry No. - 1   [TOP]
PolysacDB ID2647
Carbohydrate NameSerotype b-specific polysaccharide antigen   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeActinobacillus actinomycetemcomitans Y4   (NCBI Taxonomy)   (Drugpedia)
Basic StructureSerotype b-specific antigen of A. actinomycetemcomitans is a capsular polysaccharide-like antigen consisting of a disaccharide repeating unit, 33)-a-D-fucopyranosyl-(132)-b-L-rhamnopyranosyl-(1-
BCSDB StructureN/A
Proposed functionsSPA of A. actinomycetemcomitans plays an important role in the resistance to phagocytosis and killing by human PMNs.
Antigenic Nature used to produce antibodiesWhole cells
Carrier NameN/A
Conjugation MethodN/A
AntibodiesIgG1
Antibody type and classMab S2
Assay SystemChemiluminescence (CL) assay, immunoblotting and phagocytic killing assay
Cross-reactivityN/A
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab enhanced CL responses of human PMNs to the organism and killing of the organism by human PMNs
Curator IDAA + AS
Date of Curation21-01-2012
ReferencesPMC173659


Entry No. - 2   [TOP]
PolysacDB ID2648
Carbohydrate NameSerotype b-specific polysaccharide antigen   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeActinobacillus actinomycetemcomitans Y4   (NCBI Taxonomy)   (Drugpedia)
Basic StructureSerotype b-specific antigen of A. actinomycetemcomitans is a capsular polysaccharide-like antigen consisting of a disaccharide repeating unit, 33)-a-D-fucopyranosyl-(132)-b-L-rhamnopyranosyl-(1-
BCSDB StructureN/A
Proposed functionsSPA of A. actinomycetemcomitans plays an important role in the resistance to phagocytosis and killing by human PMNs.
Antigenic Nature used to produce antibodiesWhole cells
Carrier NameN/A
Conjugation MethodN/A
AntibodiesIgG2a
Antibody type and classMab S4
Assay SystemChemiluminescence (CL) assay, immunoblotting and phagocytic killing assay
Cross-reactivityN/A
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab enhanced CL responses of human PMNs to the organism and killing of the organism by human PMNs
Curator IDAA + AS
Date of Curation21-01-2012
ReferencesPMC173659


Entry No. - 3   [TOP]
PolysacDB ID2649
Carbohydrate NameSerotype b-specific polysaccharide antigen   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeActinobacillus actinomycetemcomitans Y4   (NCBI Taxonomy)   (Drugpedia)
Basic StructureSerotype b-specific antigen of A. actinomycetemcomitans is a capsular polysaccharide-like antigen consisting of a disaccharide repeating unit, 33)-a-D-fucopyranosyl-(132)-b-L-rhamnopyranosyl-(1-
BCSDB StructureN/A
Proposed functionsSPA of A. actinomycetemcomitans plays an important role in the resistance to phagocytosis and killing by human PMNs.
Antigenic Nature used to produce antibodiesWhole cells
Carrier NameN/A
Conjugation MethodN/A
AntibodiesIgG3
Antibody type and classMab S5
Assay SystemChemiluminescence (CL) assay, immunoblotting and phagocytic killing assay
Cross-reactivityN/A
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab enhanced CL responses of human PMNs to the organism and killing of the organism by human PMNs
Curator IDAA + AS
Date of Curation25-01-2012
ReferencesPMC173659


Entry No. - 4   [TOP]
PolysacDB ID2650
Carbohydrate NameSerotype b-specific polysaccharide antigen   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeActinobacillus actinomycetemcomitans Y4   (NCBI Taxonomy)   (Drugpedia)
Basic StructureSerotype b-specific antigen of A. actinomycetemcomitans is a capsular polysaccharide-like antigen consisting of a disaccharide repeating unit, 33)-a-D-fucopyranosyl-(132)-b-L-rhamnopyranosyl-(1-
BCSDB StructureN/A
Proposed functionsSPA of A. actinomycetemcomitans plays an important role in the resistance to phagocytosis and killing by human PMNs.
Antigenic Nature used to produce antibodiesWhole cells
Carrier NameN/A
Conjugation MethodN/A
AntibodiesIgG3
Antibody type and classMab S8
Assay SystemChemiluminescence (CL) assay, immunoblotting and phagocytic killing assay
Cross-reactivityN/A
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab enhanced CL responses of human PMNs to the organism and killing of the organism by human PMNs
Curator IDAA + AS
Date of Curation25-01-2012
ReferencesPMC173659


Entry No. - 5   [TOP]
PolysacDB ID2651
Carbohydrate NameSerotype b-specific polysaccharide antigen   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeActinobacillus actinomycetemcomitans Y4   (NCBI Taxonomy)   (Drugpedia)
Basic StructureSerotype b-specific antigen of A. actinomycetemcomitans is a capsular polysaccharide-like antigen consisting of a disaccharide repeating unit, 33)-a-D-fucopyranosyl-(132)-b-L-rhamnopyranosyl-(1-
BCSDB StructureN/A
Proposed functionsSPA of A. actinomycetemcomitans plays an important role in the resistance to phagocytosis and killing by human PMNs.
Antigenic Nature used to produce antibodiesWhole cells
Carrier NameN/A
Conjugation MethodN/A
AntibodiesIgM
Antibody type and classMab S9
Assay SystemChemiluminescence (CL) assay, immunoblotting and phagocytic killing assay
Cross-reactivityN/A
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab did not enhance CL responses of human PMNs to the organism and did not promote killing of the organism by human PMNs
Curator IDAA + AS
Date of Curation25-01-2012
ReferencesPMC173659


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