PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 2

Entry No. - 1   [TOP]
PolysacDB ID1464
Carbohydrate NameCapsular polysaccharide   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
MicrobeEnterococcus faecalis 12030   (NCBI Taxonomy)   (Drugpedia)
Basic StructureGlycerol teichoic acid-like molecules with a carbohydrate backbone structure of 6-α-D-glucose- 1-->2 glycerol-3-PO4 with substitution on carbon 2 of the glucose with an α-2-1-D-glucose residue
BCSDB Structure2446
Proposed functionsThese polysaccharides are major virulence factors
Antigenic Nature used to produce antibodiesGentamicin-killed Enterococcus faecalis strains
Carrier NameNil
Conjugation MethodNil
AntibodiesPolysera
Antibody type and classN/A
Assay SystemOpsonophagocytic assay, immunoelectron microscopy
Cross-reactivityThis antisera reacted with the homologous strain (12030) and mediated opsonic killing of 33% of all strains tested. In addition, this serum killed two (28%) of seven vancomycin-resistant Enterococcus faecium strains
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis antisera was opsonophagcytic
Curator IDAA + AS
Date of Curation24-07-2010
References10024563


Entry No. - 2   [TOP]
PolysacDB ID1465
Carbohydrate NameCapsular polysaccharide   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
MicrobeEnterococcus faecalis 12030   (NCBI Taxonomy)   (Drugpedia)
Basic StructureGlycerol teichoic acid-like molecules with a carbohydrate backbone structure of 6-α-D-glucose- 1-->2 glycerol-3-PO4 with substitution on carbon 2 of the glucose with an α-2-1-D-glucose residue
BCSDB Structure2446
Proposed functionsThese polysaccharides are major virulence factors
Antigenic Nature used to produce antibodiesCapsular polysaccharide
Carrier NameNil
Conjugation MethodNil
AntibodiesPolysera
Antibody type and classIgM
Assay SystemELISA and opsonophagocytic assay
Cross-reactivityThe antisera cross-reacted with Enterococcus faecalis OG1RF and against two serologically related, vancomycin-resistant Enterococcus faecium clinical isolates
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThese antibodies may be useful for prophylaxis and treatment of enterococcal infections
Curator IDAA + AS
Date of Curation25-07-2010
References15184433


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