PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 2

Entry No. - 1   [TOP]
PolysacDB ID2464
Carbohydrate NameSurface polysaccharide   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
MicrobeEubacterium saburreum strain T18   (NCBI Taxonomy)   (Drugpedia)
Basic StructureThe purified antigen was a homopolysaccharide composed of D-glycero-D-galacto-heptose (Hep.) residues. The structure of the repeating unit in the polysaccharide was: -[-6)-[α Hep.furanosyl-(1-->4)]-β-Hep.pyranosyl- (1-->6)-[α-Hep.furanosyl-(1-->2), α-Hep.furanosyl-(1-->4)]-β- Hep.pyranosyl-(1-)4-->6)-β-Hep.pyranosyl-(1-->. No heptose residues were acetylated
BCSDB StructureN/A
Proposed functionsN/A
Antigenic Nature used to produce antibodiesWhole cells
Carrier NameNil
Conjugation MethodNil
AntibodiesAntisera
Antibody type and classN/A
Assay SystemImmunodiffusion tests
Cross-reactivityN/A
Proposed epitopesThe immunodeterminant of the antigenic polysaccharide was D-glycero-D-galacto-heptofuranosyl residues as branched nonreducing terminals
IEDB EpitopeN/A
Proposed UtilityN/A
Curator IDAA + AS
Date of Curation25-05-2011
References1408355


Entry No. - 2   [TOP]
PolysacDB ID2470
Carbohydrate NameSurface polysaccharide antigen   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
MicrobeEubacterium saburreum strain T18   (NCBI Taxonomy)   (Drugpedia)
Basic StructureThis antigen was composed of D-glycero-D-galacto-heptose
BCSDB StructureN/A
Proposed functionsN/A
Antigenic Nature used to produce antibodiesWhole cells
Carrier NameNil
Conjugation MethodNil
AntibodiesAntisera
Antibody type and classIgM
Assay SystemImmunoprecipitation, immunodiffusion
Cross-reactivityThis antisera was specific to T18 antigen and did not cross-react with L44 antigen and T27 antigen
Proposed epitopesD-glycero-D-galacto-heptose constitutes part of the immunodeterminant of the antigenic polysaccharide
IEDB EpitopeN/A
Proposed UtilityThe polysaccharide antigen from strain T18 is distinct from those previously reported for this species and may be useful in serotyping E. saburreum
Curator IDAA + AS
Date of Curation28-05-2011
ReferencesPMC260431


Bioinformatics Centre, Institute of Microbial Technology, Sec - 39A, Chandigarh, India - 160036