PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 8

Entry No. - 1   [TOP]
PolysacDB ID1517
Carbohydrate NameCapsular polysaccharide   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
MicrobeKlebsiella pneumoniae   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed functionsCPS have been shown to be important virulence factors and potent Ag for the induction of immunoprotection
Antigenic Nature used to produce antibodiesA 24-valent K. pneumoniae CPS vaccine containing the serotypes 2, 3, 5, 9, 10, 15, 16. 17, 18, 21, 22, 25, 28. 30, 35, 43, 52, 53, 55, 60, 61, 62, 63, and 64
Carrier NameNil
Conjugation MethodNil
AntibodiesMab MT 74 H31
Antibody type and classIgA
Assay SystemELISA and immunofluorescence
Cross-reactivityThis Mab recognised K16 and K17 strains
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab may prove valuable as diagnostic tools and that an immunotherapy is feasible
Curator IDAA + AS
Date of Curation10-08-2010
References2016541


Entry No. - 2   [TOP]
PolysacDB ID1518
Carbohydrate NameCapsular polysaccharide   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
MicrobeKlebsiella pneumoniae   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed functionsCPS have been shown to be important virulence factors and potent Ag for the induction of immunoprotection
Antigenic Nature used to produce antibodiesA 24-valent K. pneumoniae CPS vaccine containing the serotypes 2, 3, 5, 9, 10, 15, 16. 17, 18, 21, 22, 25, 28. 30, 35, 43, 52, 53, 55, 60, 61, 62, 63, and 64
Carrier NameNil
Conjugation MethodNil
AntibodiesMab S3-4H68
Antibody type and classIgM
Assay SystemELISA and immunofluorescence
Cross-reactivityThis Mab recognised K26, K30 and K69 strains
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab may prove valuable as diagnostic tools and that an immunotherapy is feasible
Curator IDAA + AS
Date of Curation19-08-2010
References2016541


Entry No. - 3   [TOP]
PolysacDB ID1519
Carbohydrate NameCapsular polysaccharide   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
MicrobeKlebsiella pneumoniae   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed functionsCPS have been shown to be important virulence factors and potent Ag for the induction of immunoprotection
Antigenic Nature used to produce antibodiesA 24-valent K. pneumoniae CPS vaccine containing the serotypes 2, 3, 5, 9, 10, 15, 16. 17, 18, 21, 22, 25, 28. 30, 35, 43, 52, 53, 55, 60, 61, 62, 63, and 64
Carrier NameNil
Conjugation MethodNil
AntibodiesMab KJ6-1H74
Antibody type and classIgM
Assay SystemELISA and immunofluorescence
Cross-reactivityThis Mab recognised K30, K82 and K69 strains
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab may prove valuable as diagnostic tools and that an immunotherapy is feasible
Curator IDAA + AS
Date of Curation19-08-2010
References2016541


Entry No. - 4   [TOP]
PolysacDB ID1520
Carbohydrate NameCapsular polysaccharide   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
MicrobeKlebsiella pneumoniae   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed functionsCPS have been shown to be important virulence factors and potent Ag for the induction of immunoprotection
Antigenic Nature used to produce antibodiesA 24-valent K. pneumoniae CPS vaccine containing the serotypes 2, 3, 5, 9, 10, 15, 16. 17, 18, 21, 22, 25, 28. 30, 35, 43, 52, 53, 55, 60, 61, 62, 63, and 64
Carrier NameNil
Conjugation MethodNil
AntibodiesMab MT133 H26
Antibody type and classIgM
Assay SystemELISA and immunofluorescence
Cross-reactivityThis Mab recognised K16 and K17 strains
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab may prove valuable as diagnostic tools and that an immunotherapy is feasible
Curator IDAA + AS
Date of Curation20-08-2010
References2016541


Entry No. - 5   [TOP]
PolysacDB ID1521
Carbohydrate NameCapsular polysaccharide   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
MicrobeKlebsiella pneumoniae   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed functionsCPS have been shown to be important virulence factors and potent Ag for the induction of immunoprotection
Antigenic Nature used to produce antibodiesA 24-valent K. pneumoniae CPS vaccine containing the serotypes 2, 3, 5, 9, 10, 15, 16. 17, 18, 21, 22, 25, 28. 30, 35, 43, 52, 53, 55, 60, 61, 62, 63, and 64
Carrier NameNil
Conjugation MethodNil
AntibodiesMab MT71 H105
Antibody type and classIgM
Assay SystemELISA and immunofluorescence
Cross-reactivityThis Mab recognised K55 strains
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab may prove valuable as diagnostic tools and that an immunotherapy is feasible
Curator IDAA + AS
Date of Curation20-08-2010
References2016541


Entry No. - 6   [TOP]
PolysacDB ID1522
Carbohydrate NameCapsular polysaccharide   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
MicrobeKlebsiella pneumoniae   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed functionsCPS have been shown to be important virulence factors and potent Ag for the induction of immunoprotection
Antigenic Nature used to produce antibodiesA 24-valent K. pneumoniae CPS vaccine containing the serotypes 2, 3, 5, 9, 10, 15, 16. 17, 18, 21, 22, 25, 28. 30, 35, 43, 52, 53, 55, 60, 61, 62, 63, and 64
Carrier NameNil
Conjugation MethodNil
AntibodiesMab MT72 H99
Antibody type and classIgM
Assay SystemELISA and immunofluorescence
Cross-reactivityThis Mab recognised K5, K6, K7, K10, K20, K49, K61, K62, K64 and K74 strains
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab may prove valuable as diagnostic tools and that an immunotherapy is feasible
Curator IDAA + AS
Date of Curation21-08-2010
References2016541


Entry No. - 7   [TOP]
PolysacDB ID1523
Carbohydrate NameCapsular polysaccharide   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
MicrobeKlebsiella pneumoniae   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed functionsCPS have been shown to be important virulence factors and potent Ag for the induction of immunoprotection
Antigenic Nature used to produce antibodiesA 24-valent K. pneumoniae CPS vaccine containing the serotypes 2, 3, 5, 9, 10, 15, 16. 17, 18, 21, 22, 25, 28. 30, 35, 43, 52, 53, 55, 60, 61, 62, 63, and 64
Carrier NameNil
Conjugation MethodNil
AntibodiesMT168 H11
Antibody type and classIgA
Assay SystemELISA and immunofluorescence
Cross-reactivityThis Mab recognized K3, K68 and K46
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab may prove valuable as diagnostic tools and that an immunotherapy is feasible
Curator IDAA + AS
Date of Curation21-08-2010
References2016541


Entry No. - 8   [TOP]
PolysacDB ID1524
Carbohydrate NameCapsular polysaccharide   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
MicrobeKlebsiella pneumoniae   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed functionsCPS have been shown to be important virulence factors and potent Ag for the induction of immunoprotection
Antigenic Nature used to produce antibodiesA 24-valent K. pneumoniae CPS vaccine containing the serotypes 2, 3, 5, 9, 10, 15, 16. 17, 18, 21, 22, 25, 28. 30, 35, 43, 52, 53, 55, 60, 61, 62, 63, and 64
Carrier NameNil
Conjugation MethodNil
AntibodiesS2-A H92
Antibody type and classIgA
Assay SystemELISA and immunofluorescence
Cross-reactivityThis Mab recognized K9, K79 and K81 strains
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab may prove valuable as diagnostic tools and that an immunotherapy is feasible
Curator IDAA + AS
Date of Curation22-08-2010
References2016541


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