PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613

Total Entries - 8
Entry No. - 1 [TOP]

PolysacDB ID	1525
Carbohydrate Name	Lipopolysaccharide (Drugpedia)
Carbohydrate Class	Lipopolysaccharide
Microbe	Klebsiella pneumoniae O1:K2 (NCBI Taxonomy) (Drugpedia)
Basic Structure	N/A
BCSDB Structure	N/A
Proposed functions	It has been shown to be an important virulence factor and potent antigen for the induction of immunoprotection
Antigenic Nature used to produce antibodies	LPS-associated proteins plus LPS
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 2A4
Antibody type and class	IgG3
Assay System	ELISA
Cross-reactivity	This Mab did not cross-react with LPS from Klebsiella strains of the 02, 03, and 04 serotypes nor LPS from E. coli 0111:B4
Proposed epitopes	This Mab recognized O-antigen
IEDB Epitope	N/A
Proposed Utility	N/A
Curator ID	AA + AS
Date of Curation	22-08-2010
References	PMC313574

Entry No. - 2 [TOP]

PolysacDB ID	1526
Carbohydrate Name	Lipopolysaccharide (Drugpedia)
Carbohydrate Class	Lipopolysaccharide
Microbe	Klebsiella pneumoniae O1:K2 (NCBI Taxonomy) (Drugpedia)
Basic Structure	N/A
BCSDB Structure	N/A
Proposed functions	It has been shown to be an important virulence factor and potent antigen for the induction of immunoprotection
Antigenic Nature used to produce antibodies	LPS-associated proteins plus LPS
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 3A3
Antibody type and class	IgM
Assay System	ELISA
Cross-reactivity	This Mab cross-reacted with K. pneumoniae R:K18, a rough strain. This Mab did not cross-react with LPS from Klebsiella strains of the 02, 03, and 04 serotypes nor LPS from E. coli 0111:B4
Proposed epitopes	This Mab recognized the LPS core
IEDB Epitope	N/A
Proposed Utility	N/A
Curator ID	AA + AS
Date of Curation	23-08-2010
References	PMC313574

Entry No. - 3 [TOP]

PolysacDB ID	1527
Carbohydrate Name	Lipopolysaccharide (Drugpedia)
Carbohydrate Class	Lipopolysaccharide
Microbe	Klebsiella pneumoniae O1:K2 (NCBI Taxonomy) (Drugpedia)
Basic Structure	N/A
BCSDB Structure	N/A
Proposed functions	It has been shown to be an important virulence factor and potent antigen for the induction of immunoprotection
Antigenic Nature used to produce antibodies	LPS-associated proteins plus LPS
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 3C2
Antibody type and class	IgM
Assay System	ELISA
Cross-reactivity	This Mab cross-reacted with K. pneumoniae R:K18, a rough strain. This Mab did not cross-react with LPS from Klebsiella strains of the 02, 03, and 04 serotypes nor LPS from E. coli 0111:B4
Proposed epitopes	This Mab recognized the LPS core
IEDB Epitope	N/A
Proposed Utility	N/A
Curator ID	AA + AS
Date of Curation	23-08-2010
References	PMC313574

Entry No. - 4 [TOP]

PolysacDB ID	1528
Carbohydrate Name	Lipopolysaccharide (Drugpedia)
Carbohydrate Class	Lipopolysaccharide
Microbe	Klebsiella pneumoniae O1:K2 (NCBI Taxonomy) (Drugpedia)
Basic Structure	N/A
BCSDB Structure	N/A
Proposed functions	It has been shown to be an important virulence factor and potent antigen for the induction of immunoprotection
Antigenic Nature used to produce antibodies	LPS-associated proteins plus LPS
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 3C4
Antibody type and class	IgM
Assay System	ELISA
Cross-reactivity	This Mab cross-reacted with K. pneumoniae R:K18, a rough strain. This Mab did not cross-react with LPS from Klebsiella strains of the 02, 03, and 04 serotypes nor LPS from E. coli 0111:B4
Proposed epitopes	This Mab recognized the LPS core
IEDB Epitope	N/A
Proposed Utility	This Mab showed invivo protection in mice against LPS induced homologous shock
Curator ID	AA + AS
Date of Curation	23-08-2010
References	PMC313574

Entry No. - 5 [TOP]

PolysacDB ID	1529
Carbohydrate Name	Lipopolysaccharide (Drugpedia)
Carbohydrate Class	Lipopolysaccharide
Microbe	Klebsiella pneumoniae O1:K2 (NCBI Taxonomy) (Drugpedia)
Basic Structure	N/A
BCSDB Structure	N/A
Proposed functions	It has been shown to be an important virulence factor and potent antigen for the induction of immunoprotection
Antigenic Nature used to produce antibodies	LPS-associated proteins plus LPS
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 6D5
Antibody type and class	IgG3
Assay System	ELISA
Cross-reactivity	This Mab did not cross-react with K. pneumoniae R:K18, a rough strain. This Mab did not cross-react with LPS from Klebsiella strains of the 02, 03, and 04 serotypes nor LPS from E. coli 0111:B4
Proposed epitopes	This Mab recognized the LPS core
IEDB Epitope	N/A
Proposed Utility	This Mab showed invivo protection in mice against LPS induced homologous shock
Curator ID	AA + AS
Date of Curation	26-08-2010
References	PMC313574

Entry No. - 6 [TOP]

PolysacDB ID	1530
Carbohydrate Name	Lipopolysaccharide (Drugpedia)
Carbohydrate Class	Lipopolysaccharide
Microbe	Klebsiella pneumoniae O1:K2 (NCBI Taxonomy) (Drugpedia)
Basic Structure	N/A
BCSDB Structure	N/A
Proposed functions	It has been shown to be an important virulence factor and potent antigen for the induction of immunoprotection
Antigenic Nature used to produce antibodies	LPS-associated proteins plus LPS
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 7D2
Antibody type and class	IgG2b
Assay System	ELISA
Cross-reactivity	This Mab cross-reacted with K. pneumoniae R:K18, a rough strain. This Mab did not cross-react with LPS from Klebsiella strains of the 02, 03, and 04 serotypes nor LPS from E. coli 0111:B4
Proposed epitopes	This Mab recognized the LPS core
IEDB Epitope	N/A
Proposed Utility	This Mab showed invivo protection in mice against LPS induced homologous shock
Curator ID	AA + AS
Date of Curation	26-08-2010
References	PMC313574

Entry No. - 7 [TOP]

PolysacDB ID	1531
Carbohydrate Name	Lipopolysaccharide (Drugpedia)
Carbohydrate Class	Lipopolysaccharide
Microbe	Klebsiella pneumoniae O1:K2 (NCBI Taxonomy) (Drugpedia)
Basic Structure	N/A
BCSDB Structure	N/A
Proposed functions	It has been shown to be an important virulence factor and potent antigen for the induction of immunoprotection
Antigenic Nature used to produce antibodies	LPS-associated proteins plus LPS
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 11C3
Antibody type and class	IgG2b
Assay System	ELISA
Cross-reactivity	This Mab cross-reacted with K. pneumoniae R:K18, a rough strain. This Mab did not cross-react with LPS from Klebsiella strains of the 02, 03, and 04 serotypes nor LPS from E. coli 0111:B4
Proposed epitopes	This Mab recognized the LPS core
IEDB Epitope	N/A
Proposed Utility	This Mab showed invivo protection in mice against LPS induced homologous shock
Curator ID	AA + AS
Date of Curation	26-08-2010
References	PMC313574

Entry No. - 8 [TOP]

PolysacDB ID	1532
Carbohydrate Name	Lipopolysaccharide (Drugpedia)
Carbohydrate Class	Lipopolysaccharide
Microbe	Klebsiella pneumoniae O1:K2 (NCBI Taxonomy) (Drugpedia)
Basic Structure	N/A
BCSDB Structure	N/A
Proposed functions	It has been shown to be an important virulence factor and potent antigen for the induction of immunoprotection
Antigenic Nature used to produce antibodies	LPS-associated proteins plus LPS
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 12B6
Antibody type and class	IgG3
Assay System	ELISA
Cross-reactivity	This Mab cross-reacted with K. pneumoniae R:K18, a rough strain. This Mab did not cross-react with LPS from Klebsiella strains of the 02, 03, and 04 serotypes nor LPS from E. coli 0111:B4
Proposed epitopes	This Mab recognized the LPS core
IEDB Epitope	N/A
Proposed Utility	This Mab showed invivo protection in mice against LPS induced homologous shock
Curator ID	AA + AS
Date of Curation	27-08-2010
References	PMC313574

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