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| PolysacDB ID | 1572 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Neisseria meningitidis strain P355 (group B) (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a homopolymer of α(2-->8) sialic acid |
| BCSDB Structure | N/A |
| Proposed functions | This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins |
| Antigenic Nature used to produce antibodies | Viable meningococci strain P355 (group B] |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab 2-1-B |
| Antibody type and class | IgM |
| Assay System | Quantitative precipitation analysis, Antigen-binding assay |
| Cross-reactivity | N/A |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab was bactericidal with human C strain and opsonized K1 polysaccharide containing E. coli in an opsonophagocytic assay with human C strain |
| Curator ID | AA + AS |
| Date of Curation | 11-09-2010 |
| References | 6811660 |
| PolysacDB ID | 1573 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Neisseria meningitidis strain P355 (group B) (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a homopolymer of α(2-->8) sialic acid |
| BCSDB Structure | N/A |
| Proposed functions | This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins |
| Antigenic Nature used to produce antibodies | Viable meningococci strain P355 (group B] |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab 2-2-B |
| Antibody type and class | IgM |
| Assay System | Quantitative precipitation analysis, Antigen-binding assay |
| Cross-reactivity | N/A |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab was bactericidal with human C strain and opsonized K1 polysaccharide containing E. coli in an opsonophagocytic assay with human C strain |
| Curator ID | AA + AS |
| Date of Curation | 11-09-2010 |
| References | 6811660 |
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Bioinformatics Centre, Institute of Microbial Technology, Sec - 39A, Chandigarh, India - 160036 |