PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 4

Entry No. - 1   [TOP]
PolysacDB ID2405
Carbohydrate NameCell wall antigen (SA I/II)   (Drugpedia)
Carbohydrate ClassGlycoprotein
MicrobeStreptococcus mutans serotype c   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed functionsN/A
Antigenic Nature used to produce antibodiesCell wall antigen (SA I/II)
Carrier NameNil
Conjugation MethodNil
AntibodiesMab Guy 1
Antibody type and classIgG2a
Assay SystemSolid-phase radioimmunoassy, Competitive inhibition experiments
Cross-reactivityThis Mab was raised against specific carbohydrate epitopes on the SA and not against contaminating c polysaccharide in the SA preparation and was specific to serotype c
Proposed epitopesGlucose is part of the epitopes of SA recognized by this Mab
IEDB EpitopeN/A
Proposed UtilityHis Mab can be used in local passive immunization to prevent colonization of S. mutans and the development of caries in monkeys and to prevent colonization of S. mutans in human subjects
Curator IDAA + AS
Date of Curation01-05-2011
References2434429


Entry No. - 2   [TOP]
PolysacDB ID2406
Carbohydrate NameCell wall antigen (SA I/II)   (Drugpedia)
Carbohydrate ClassGlycoprotein
MicrobeStreptococcus mutans serotype c   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed functionsN/A
Antigenic Nature used to produce antibodiesCell wall antigen (SA I/II)
Carrier NameNil
Conjugation MethodNil
AntibodiesMab Guy 2
Antibody type and classIgG1
Assay SystemSolid-phase radioimmunoassy, Competitive inhibition experiments
Cross-reactivityThis Mab was raised against specific carbohydrate epitopes on the SA and not against contaminating c polysaccharide in the SA preparation and was specific to serotype c
Proposed epitopesGlucose is part of the epitopes of SA recognized by this Mab
IEDB EpitopeN/A
Proposed UtilityHis Mab can be used in local passive immunization to prevent colonization of S. mutans and the development of caries in monkeys and to prevent colonization of S. mutans in human subjects
Curator IDAA + AS
Date of Curation01-05-2011
References2434429


Entry No. - 3   [TOP]
PolysacDB ID2407
Carbohydrate NameCell wall antigen (SA I/II)   (Drugpedia)
Carbohydrate ClassGlycoprotein
MicrobeStreptococcus mutans serotype c   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed functionsN/A
Antigenic Nature used to produce antibodiesCell wall antigen (SA I/II)
Carrier NameNil
Conjugation MethodNil
AntibodiesMab Guy 3
Antibody type and classIgG2a
Assay SystemSolid-phase radioimmunoassy, Competitive inhibition experiments
Cross-reactivityThis Mab was raised against specific carbohydrate epitopes on the SA and not against contaminating c polysaccharide in the SA preparation and was specific to serotype c
Proposed epitopesGlucose is part of the epitopes of SA recognized by this Mab
IEDB EpitopeN/A
Proposed UtilityHis Mab can be used in local passive immunization to prevent colonization of S. mutans and the development of caries in monkeys and to prevent colonization of S. mutans in human subjects
Curator IDAA + AS
Date of Curation01-05-2011
References2434429


Entry No. - 4   [TOP]
PolysacDB ID2408
Carbohydrate NameCell wall antigen (SA I/II)   (Drugpedia)
Carbohydrate ClassGlycoprotein
MicrobeStreptococcus mutans serotype c   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed functionsN/A
Antigenic Nature used to produce antibodiesCell wall antigen (SA I/II)
Carrier NameNil
Conjugation MethodNil
AntibodiesMab Guy 5
Antibody type and classIgG1
Assay SystemSolid-phase radioimmunoassy, Competitive inhibition experiments
Cross-reactivityThis Mab was raised against specific carbohydrate epitopes on the SA and not against contaminating c polysaccharide in the SA preparation and was specific to serotype c
Proposed epitopesGlucose is part of the epitopes of SA recognized by this Mab
IEDB EpitopeN/A
Proposed UtilityHis Mab can be used in local passive immunization to prevent colonization of S. mutans and the development of caries in monkeys and to prevent colonization of S. mutans in human subjects
Curator IDAA + AS
Date of Curation02-05-2011
References2434429


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