| PolysacDB ID | 2434 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Streptococcus suis serotype 2 reference strain S735 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | N/A
|
| BCSDB Structure | N/A |
| Proposed functions | It is an important virulence factor |
| Antigenic Nature used to produce antibodies | Whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab Z3 |
| Antibody type and class | IgG2b |
| Assay System | Dot-ELISA, immunoblotting, electron microscopy, Opsonization and phagocytic assay, Protection assay, Bacterial clearance test |
| Cross-reactivity | This Mab reacted only with reference strains and field isolates of S. suis serotypes 1,2 and 1/2 |
| Proposed epitopes | Mab Z3 reacts specifically with the sialic acid moiety of the capsule, a common constituent of the polysaccharidic capsular material of the three capsular types |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab was able to stabilize the capsule as shown by electron microscopy. Purified mAb Z3 was shown to significantly increase the rate of phagocytosis of S. suis cells by porcine monocytes and to activate the clearance of bacteria from the circulation in experimentally infected mice. mAb Z3 only offered partial protection to mice challenged with a minimal lethal dose |
| Curator ID | AA + AS |
| Date of Curation | 12-05-2011
|
| References | 9387239 |